Desmopressin Nasal Spray: What It Is and When to Use It
Desmopressin nasal spray is a medication that mimics the hormone vasopressin. It tells your kidneys to hold onto water, which cuts down on the amount of urine you make. Doctors usually prescribe it for three main reasons: diabetes insipidus, nocturnal bedwetting, and certain bleeding disorders.
If you’ve been told you have diabetes insipidus, your body can’t control water balance, so you pee a lot and feel thirsty all the time. A few sprays in each nostril can bring that back to normal. For kids and teens who wet the bed, a low‑dose spray before bedtime often does the trick. And for people with mild hemophilia or von Willebrand disease, desmopressin can boost clotting factors for a short period before a procedure.
How to Take Desmopressin Nasal Correctly
First, read the label and your doctor’s instructions. Most doses are measured in micrograms (µg) per spray. Shake the bottle gently, then prime it by spraying a few times into the air until you see a fine mist. Aim the nozzle toward the outer wall of each nostril, not the center, and press down once. Avoid blowing your nose for at least 15 minutes after use.
Timing matters. Take the spray at the same time each day, usually in the morning for diabetes insipidus or right before bedtime for bedwetting. If you miss a dose, take it as soon as you remember unless it’s close to your next dose – then just skip it and continue with your regular schedule.
Possible Side Effects and What to Watch For
Desmopressin is generally safe when used as directed, but it can cause side effects. Common ones include mild headache, nasal irritation, or a stuffy nose. More serious issues involve water retention, which can lead to low sodium levels (hyponatremia). Signs of hyponatremia include nausea, dizziness, confusion, or swelling in the hands or feet. If any of these pop up, call your doctor right away.
Because the drug affects water balance, drink enough fluids to stay hydrated but avoid binge‑drinking large amounts of water in a short time. Your doctor may ask for regular blood tests to check sodium levels, especially when you start treatment or change doses.
Never share your spray with anyone else, even if they have the same condition. The dose is personalized, and sharing can cause unsafe blood‑sodium levels.
In summary, desmopressin nasal spray works by reducing urine output and can improve quality of life for people with diabetes insipidus, bedwetting, or mild bleeding disorders. Use it exactly as prescribed, keep an eye on side effects, and stay in touch with your healthcare provider for routine monitoring. With the right approach, the spray can be a simple, effective tool for managing water balance and preventing nighttime accidents.